Get Informed: Premarin
Active Ingredient(s)
Premarin
What does it do?
This product is primarily used in the treatment of menopause symptoms. It is synthetic hormone replacement.
- Last Text Update:
- 2010-Mar-10 6:49 AM
- Last Data Update:
- 2010-Mar-09 9:01 PM
Other Names
- Premarin
- Cenestin
- Premarin Vaginal
- Conjugated Estrogens
- Enjuvia
- Premarin Compositum
- Estrogenon
- Estrogens Conjugated
- Estroplus
- SCE-A
How Safe Is It?
- Your Risk Rating
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- Average Risk Rating
-
- Pregnancy Category:
- X
Black Box Warning
This product has a black box warning relating to increased risk of endometrial cancers and an increased risk of blood clots, heart attacks, invasive breast cancer, and dementia.
Facts & Figures
- Date Approved
- 08 May 1942
- Est US Patients*
- 1,762,000
- Generic Available
- No
- OTC Available
- No
User Age Distribution*
< 21
21-39
40-59
60+
Age (Years)
* Estimated number of US people currently taking Premarin or its active ingredient based on population adjusted patient numbers registered with iGuard.org.
Premarin Safety Report
Learn more about iGuard's risk ratings
- Please login or register (it's free) so iGuard can check how Premarin interacts with other drugs and diseases in your profile.
What is Premarin used for?
iGuard is currently tracking more than 11,600 patients that use Premarin (or similar drugs with the same active ingredient(s)). Use the table below to learn why iGuard users take this product; click on any underlined condition to get information on other medications used for treatment.
| Disease / Condition | % | Average Severity |
|---|---|---|
| Menopausal Symptoms | 97% | 
|
| Other | 3% |
|
How well does Premarin work?
iGuard regularly polls our more than 11,600 users taking Premarin (or similar drugs with the same active ingredient(s)) using the Treatment Satisfaction Questionnaire for Medications (TSQM) . This feedback is continuously updated in tables below for the benefit of the iGuard community. To request scores for specific patient subgroups, please contact research@iguard.org.
Average Satisfaction Score
(out of 10)
Average Effectiveness Score
(out of 10)
- 81%
- of patients are confident that the good things about Premarin outweigh the bad things.
- 8%
- of patients wish they were told more before they started taking Premarin.
Common Side Effects of Premarin
iGuard regularly polls our more than 11,600 users taking Premarin (or similar drugs with the same active ingredient(s)) to monitor the development and frequency of side-effects. This feedback is continuously updated in tables and graphs below for the benefit of the iGuard community.
14% of patients experience side-effects on Premarin
1% of patients experience signifcant side-effects on Premarin
Most Common Side Effects...
-
= 10%
Less than 1%: Breast Tenderness, Bruising, Grogginess/Confusion, Hair Loss, Headache, Hot Flashes, Itch/Rash, Light Sensitivity, Loss of Libido, Memory/Speech Problems, Mood/Behavior Changes, Muscle Pain/Cramps, Nausea/Vomiting, Sweating, Swelling/Edema, Weight Gain
Global Patient Feedback for Premarin ( Post a comment )
Question/Comment:
I have been taking premarin since the early 1980s and have had many more benefits than side effects and will never stop taking it! Birdgirl
51 year old Female – Source: iGuard United States
Posted: 2010-02-17 05:03:15
Answer/Reply:
I too have been taking Premarin for many years... 16 years and plan on taking it for the rest of my life.... I am 65, wear size 6, feel and look great and really believe in the importance of Quality of life!
65 year old Female – Source: iGuard United States
Posted: 2010-03-07 23:12:55
Question/Comment:
I am a 75-year-old woman and look as if I am in my early 60's. That is what everyone tells me. No one can believe I am this age. I had a hysterectomy (ovaries intact) when I was 40 and started taking Premarin when I was 48 and still am on it. At first I started on a higher dose, but now I take 0.3 mg every other day and I feel wonderful. I wear a size 8, do not have any serious health problems. When I have blood and urine workups everything comes back normal,except for my cholesterol which is a little high. I go dancing every Friday, do all types of dancing and wear heels. Since I feel and look so good I really think it has to be the Premarin and will continue to take it.
75 year old Female – Source: iGuard United States
Posted: 2010-02-15 12:19:46
Question/Comment:
I am a 70 year old female. I had a hysterectomy in 1984 and started taking Premarin .625 shortly after. I took it for over 20 years until new studies claimed it could cause more problems than it prevented. Within a year of stopping Premarin I could not tolerate intercourse with my husband. The vaginal area was tearing and bleeding. None of the creams helped. As sexual intercourse is a very important part of our lives, I chose to go back on Premarin.
71 year old Female – Source: iGuard United States
Posted: 2010-01-29 13:30:13
Question/Comment:
I had ovarian cancer at 17 and had to have a total hysterectomy. I have been on premarin 2.5 ever since. i am now 25 years young. i have had no problems---the doctor assures me that in my case the benefits DEFINATELY out weigh the risk involved in not havinga hormone replacement.
25 year old Female – Source: iGuard United States
Posted: 2009-10-05 16:53:27
iGuard Answer/Reply:
Hormone replacement is a very individualized decision between the patient and their doctor. While there are some significant benefits, there are also risks and side effects to consider. You should continue to have ongoing discussions with your doctor to determine if estrogen replacement is right for you.
Posted: 2009-11-05 13:18:44
Question/Comment:
I had been on a 0.625 dosage of premarin for 7 years following a total hysterectomy, I was 40 yrs old when the procedure was performed. In March of 2006 my dosage was was lowered to 0.35 or so in August of 2007 I developed a rash that itched intensely and caused skin loss, I developed alopecia, toenail and fingernail abnormalities,elevated blood pressure from normal to 190,vomiting,nausea,breast tenderness,mouth tenderness with swelling of my gums and permanent scars over 65% of my body. I was diagnosed with Lichen Planus Disease which abated when I stopped taking premarin during my illness,it has been almost 2 years and I still have dark spots over 50% of my body my blood pressure is back to 120 except for feeling generally tired I'm ok .Are Auto-immune diseases associated with premarin?
48 year old Female – Source: iGuard United States
Posted: 2009-10-01 19:12:32
iGuard Answer/Reply:
Auto-immune diseases like Lichen Planus, are not typically associated with Premarin. It is difficult to pinpoint exactly what triggers an auto-immune disease and it may be a coincidence. Your doctor is the best person to answer this question since he or she will have your complete medical history and can determine if Premarin is related to your Lichen Planus Disease.
Posted: 2009-11-01 22:27:44
You may post comments for the benefit of other patients or post questions other patients might be able to answer. Comments are submitted for possible publication on the condition that they may be edited. Only your age and gender will be published with your comment, although your other user details will be securely recorded for verification purposes.
Comments may be either questions or answers to previously posted questions. Any iGuard.org user may post questions and reply.
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Patient Comments about
Premarin