Get Informed: Lotrel
Active Ingredient(s)
Lotrel
What does it do?
This product is used in the treatment of high blood pressure. It contains a calcium channel blocker (amlodipine) and an ACE inhibitor (benazepril).
- Last Text Update:
- 2010-Mar-17 9:28 PM
- Last Data Update:
- 2010-Mar-17 9:01 PM
Other Names
- Lotrel
- Amlodipine Besylate with Benazepril
How Safe Is It?
- Your Risk Rating
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- Average Risk Rating
-
- Pregnancy Category:
- D
Black Box Warning
This product has a black box warning relating to its risks in pregnancy.
Facts & Figures
- Date Approved
- 03 Mar 1995
- Est US Patients*
- 1,152,000
- Generic Available
- Yes
- OTC Available
- No
User Age Distribution*
< 21
21-39
40-59
60+
Age (Years)
* Estimated number of US people currently taking Lotrel or its active ingredient based on population adjusted patient numbers registered with iGuard.org.
Recent alerts for Lotrel
There have been no iGuard.org alerts regarding Lotrel during the past year.
Lotrel Safety Report
Learn more about iGuard's risk ratings
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What is Lotrel used for?
iGuard is currently tracking more than 7,600 patients that use Lotrel (or similar drugs with the same active ingredient(s)). Use the table below to learn why iGuard users take this product; click on any underlined condition to get information on other medications used for treatment.
| Disease / Condition | % | Average Severity |
|---|---|---|
| High Blood Pressure | 100% | 
|
| Heart Valve Problems | 2% | 
|
How well does Lotrel work?
iGuard regularly polls our more than 7,600 users taking Lotrel (or similar drugs with the same active ingredient(s)) using the Treatment Satisfaction Questionnaire for Medications (TSQM) . This feedback is continuously updated in tables below for the benefit of the iGuard community. To request scores for specific patient subgroups, please contact research@iguard.org.
Average Satisfaction Score
(out of 10)
Average Effectiveness Score
(out of 10)
- 88%
- of patients are confident that the good things about Lotrel outweigh the bad things.
- 6%
- of patients wish they were told more before they started taking Lotrel.
Common Side Effects of Lotrel
iGuard regularly polls our more than 7,600 users taking Lotrel (or similar drugs with the same active ingredient(s)) to monitor the development and frequency of side-effects. This feedback is continuously updated in tables and graphs below for the benefit of the iGuard community.
19% of patients experience side-effects on Lotrel
< 1% of patients experience signifcant side-effects on Lotrel
Most Common Side Effects...
-
Cough
-
= 10%
Less than 1%: Bone/Joint Pain, Dizziness, Dryness, Fatigue, Itch/Rash, Postural Hypotension, Skin/Nail Problems, Swelling/Edema
Global Patient Feedback for Lotrel ( Post a comment )
Question/Comment:
I'm 51 and have been taking a generic version of Lotrel for over a year. I have had some ankle swelling on occasion, but found that it wasn't the drug but the fact that I sat at my desk working for too long and I wasn't getting proper leg circulation. I don't have that problem when I limit my work sessions to no more than 11/2 to 2 hours at a time before getting up for a break and walking around.
51 year old Male – Source: iGuard United States
Posted: 2010-03-06 10:10:50
Question/Comment:
I don't take Lotrel (generic) for blood pressure, but for controlling migraine headaches. I've had fewer since I started taking it (~12 yrs. ago) and no swelling anywhere. It has had no effect on my blood pressure which has always been fine.
62 year old Female – Source: iGuard United States
Posted: 2010-01-29 16:01:45
Question/Comment:
I am on Lotrel 10-20mg and geodon 120mg, paxil cr 25mg, topomax 20mg, diovan 160/25mg.....are there any known drug interactions with Low Dose Naltrexone? I am 57 yr old male
Thanks
58 year old Male – Source: iGuard United States
Posted: 2009-10-07 20:11:25
iGuard Answer/Reply:
There are no drug interactions between Naltrexone and Geodon, Paxil, Topamax, or Diovan listed in the iGuard drug interaction database. However, there is a potential interaction between Naltrexone and Benzapril, one of the ingredients in Lotrel. Using Benazepril and Naltrexone together may significantly increase the risk of liver problems. As a result, the use of these drugs together is normally avoided. It is best to discuss the addition or use of this medication with your physician who has your complete medical history and medication list. You may find that the benefits of the medication will outweigh the possible risks.
Posted: 2009-11-05 01:54:17
Question/Comment:
Will Lotrel cause swelling in thr legs, aankles and feet?
64 year old Male – Source: iGuard United States
Posted: 2009-08-01 19:57:52
iGuard Answer/Reply:
Some of the most common side effects of Lotrel include swelling of the feet, legs and ankles. If the swelling worsens or persists you should contact your doctor to discuss. In addition if you experience swelling of your face, tongue, throat, or neck you should immediately report that to your doctor.
Posted: 2009-08-06 22:43:38
Answer/Reply:
I was prescribed Lotrel 5-20 after getting no help from Inderal. It worked like a charm, even now after 3 yrs. But whenever I take a pain pill like Vicodin or oxycodone my left foot starts to swell towards the end of the Rx. I don't know what other meds you're taking, but I doubt it's the Lotrel.
48 year old Female – Source: iGuard United States
Posted: 2009-08-18 14:15:04
Answer/Reply:
Both my Wife and I take it and have no problems with swelling.
56 year old Male – Source: iGuard United States
Posted: 2009-08-19 19:32:58
Answer/Reply:
It may, but when I do my jogging all swelling will disappear---Does for me anyway--Good Luck
70 year old Male – Source: iGuard United States
Posted: 2009-08-20 15:21:41
Answer/Reply:
YES, IT'S NORMAL. IT WAS TOLD TO ME BY MY DOCTOR.
39 year old Male – Source: iGuard United States
Posted: 2009-08-25 22:19:07
Question/Comment:
I am a 53 yr . old female, I take alot of vitamin supplements,can they interfere with the lotrel?
53 year old Female – Source: iGuard United States
Posted: 2009-07-06 21:48:15
iGuard Answer/Reply:
There are known drug interactions with many herbal supplements and vitamins. In addition there are several that can elevate or lower blood pressure levels. Your physician as well as your pharmacist should have a complete listing of any medication you are on to make the best assessment for your condition.
Posted: 2009-07-07 14:49:26
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Comments may be either questions or answers to previously posted questions. Any iGuard.org user may post questions and reply.
64
Patient Comments about
Lotrel