Safety Alert: Quetiapine
Newer Antipsychotics Linked to Heart Risks
A recent study published in the New England Journal of Medicine reports that newer antipsychotics, such as quetiapine (Seroquel), may raise the risk of dying from sudden cardiac death. Although the study found that the risk is still relatively low - about three out of every 1,000 patients taking antipsychotic medications for one full year are expected to experience problems - it did find that the risk increases with higher doses of medication.
Although FDA approvals vary by drug, the newer antipsychotics are used for a variety of psychological conditions, including schizophrenia, autism, and bipolar disorder. However, they are also prescribed "off-label" to treat dementia, attention deficit hyperactivity disorder (ADHD), and other mood disorders. This new safety information applies to anyone taking a newer antipsychotic, regardless of the reason for taking it.
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What does this mean?
The risk of sudden death from quetiapine (Seroquel) is low, and for most patients the benefits of taking this medicine will outweigh the risks. However, if you or someone you care for is taking quetiapine (Seroquel), it is important to review your treatment with your doctor and discuss ways to reduce your risk of problems. One way is to find the lowest dose possible that still provides the most relief of your condition. Also, talk to your doctor about checking an electrocardiogram, or EKG to test the electrical activity of the heart. An EKG may identify if you have problems with the electrical system of your heart, which might place you at a greater risk while taking quetiapine (Seroquel).
